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Herbal Munziq Ameliorates Myocardial Ischemia-Reperfusion Injury by Inhibiting Inflammation
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Lycopene protects against myocardial ischemia-reperfusion injury by inhibiting mitochondrial permeability transition

Xuying Li1, Pengyu Jia1, Zijun Huang1

  • 1Department of Cardiology.

Drug Design, Development and Therapy
|August 3, 2019
PubMed
Abstract

Insights

Lycopene (LP) protects against myocardial ischemia-reperfusion injury (MIRI) by inhibiting the mitochondria permeability transition pore (MPTP). This antioxidant reduces infarct size and apoptosis by modulating Bax and Bcl-2 expression.

Area of Science:

  • Cardiovascular Research
  • Mitochondrial Biology
  • Pharmacology

Background:

  • Mitochondria permeability transition pore (MPTP) is a key target for myocardial ischemia-reperfusion injury (MIRI).
  • Lycopene (LP), a potent antioxidant, shows protective effects against MIRI, but its mechanism requires elucidation.
  • This study investigates LP's cardioprotective mechanism focusing on MPTP.

Purpose of the Study:

  • To investigate the role of MPTP in lycopene's cardioprotection against MIRI.
  • To elucidate the molecular mechanisms underlying lycopene's protective effects.

Main Methods:

  • H9c2 cells and male rat hearts were used to model MIRI.
  • Cell viability, infarct size, MPTP opening, mitochondrial membrane potential (ΔΨm), and apoptosis were assessed.
  • Protein expression of apoptosis-related factors (cytochrome c, Bax, Bcl-2, caspases) was analyzed via Western blotting.

Main Results:

  • LP pretreatment increased cell viability and reduced myocardial infarct size and apoptosis rate in MIRI models.
  • LP attenuated MPTP opening, preserved ΔΨm, and decreased pro-apoptotic protein expression.
  • LP increased Bcl-2 and decreased Bax expression, modulating the Bax/Bcl-2 ratio.

Conclusions:

  • Lycopene exerts cardioprotective effects against MIRI.
  • LP inhibits MPTP opening, a key mechanism in its protective action.
  • Modulation of Bax and Bcl-2 expression contributes to lycopene's cardioprotection in MIRI.
Keywords:
apoptosislycopenemitochondrial permeability transition poremyocardial ischemia reperfusion injury

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