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IgE level in newborn umbilical cord and its relationship with some maternal factors

Iraj Mohammadzadeh1, Mohsen Haghshenas1, Samaneh Asefi1

  • 11Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Imam Khomeini Street, Babol, 4731-741151 Iran.

Clinical and Molecular Allergy : CMA
|August 3, 2019
PubMed

Insights

Newborns

Area of Science:

  • Pediatric Allergy and Immunology
  • Neonatal Health
  • Immunoglobulin E (IgE) Research

Background:

  • Allergic diseases are a significant pediatric health concern due to their high prevalence and chronic nature.
  • Identifying contributing factors is crucial for effective prevention strategies.
  • This study focuses on neonatal immunoglobulin E (IgE) levels and maternal influences.

Purpose of the Study:

  • To investigate immunoglobulin E (IgE) levels in newborn umbilical cord blood.
  • To explore the relationship between neonatal IgE levels and various maternal factors.
  • To understand potential early indicators for allergic disease risk.

Main Methods:

  • A cross-sectional study involving 101 mothers and their newborns.
  • Data collected on maternal history (allergies, exposures) and delivery methods.
  • Neonatal umbilical cord blood and maternal serum IgE levels measured via ELISA.

Main Results:

  • Neonatal IgE levels were generally within the normal range.
  • Significantly higher IgE levels were observed in male newborns compared to females (p=0.011).
  • No significant association found between IgE levels and delivery technique or pet exposure.

Conclusions:

  • Neonatal IgE levels were within normal physiological ranges in the study population.
  • Newborn sex emerged as a significant factor influencing IgE levels.
  • Further research can explore sex-specific immune responses in early life allergy development.
Abstract

Keywords:
AllergyIgENewborns

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