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Updated: Jan 21, 2026

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology
Published on: March 17, 2016
Histological data of axons, astrocytes, and myelin in deep subcortical white matter populations
Santiago Coelho1,2, Jose M Pozo1,2, Marina Costantini2
1Centre for Computational Imaging & Simulation Technologies in Biomedicine (CISTIB) and Leeds Institute for Cardiac and Metabolic Medicine (LICAMM), School of Computing & School of Medicine, University of Leeds, Leeds, UK.
Abstract:
This immunohistochemistry dataset contains the main structures in deep subcortical white matter (axons, astrocytes, and myelinated axons) in a representative cohort of an ageing population. A set of samples from 90 subjects of the Cognitive Function and Ageing Study (CFAS) were analysed, stratified into three groups of 30 subjects each, in relation to the presence of age-associated deep subcortical lesions. High-resolution microscopy data enables the extraction of valuable information, such as volume fractions, for the construction and validation of diffusion MRI (dMRI) models. The dataset provided here was used in Coelho et al. [1].
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