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Updated: Jan 21, 2026

Combined Transcranial Magnetic Stimulation and Electroencephalography of the Dorsolateral Prefrontal Cortex
Published on: August 17, 2018
Medial prefrontal cortex in neurological diseases.
1Department of Pharmacology and Physiology, The George Washington University, Washington, District of Columbia.
The medial prefrontal cortex (mPFC) is vital for cognition and emotion. This review details its role in neurological and psychiatric disorders like depression and Alzheimer's disease.
Area of Science:
- Neuroscience
- Neurology
- Psychiatry
Background:
- The medial prefrontal cortex (mPFC) is a key brain region integrating diverse neural information.
- It significantly influences cognitive functions, emotional regulation, motivation, and social behaviors.
Purpose of the Study:
- To review preclinical and clinical research on the medial prefrontal cortex (mPFC).
- To elucidate the mPFC's role in various neurological and psychiatric conditions.
Main Methods:
- Literature review of preclinical studies.
- Analysis of clinical research findings.
Main Results:
- The medial prefrontal cortex (mPFC) is implicated in numerous disorders.
- Dysfunction is observed in depression, anxiety, schizophrenia, autism, Alzheimer's, Parkinson's, and addiction.
Conclusions:
- The medial prefrontal cortex (mPFC) is a critical hub for normal function.
- Understanding mPFC's role is essential for diagnosing and treating neurological and psychiatric diseases.
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