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Updated: Jan 21, 2026

Isolation and Kv Channel Recordings in Murine Atrial and Ventricular Cardiomyocytes
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Published on: March 12, 2013

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Nkx2.5 Based Ventricular Programming of Murine ESC-Derived Cardiomyocytes

Frauke Thiele1,2, Christin Voelkner1, Vivien Krebs1

  • 1Department of Cardiac Surgery, Reference and Translation Center for Cardiac Stem Cell Therapy (RTC), University Medicine Rostock, Rostock, Germany.

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
|August 3, 2019
PubMed
Summary

This study enhances cardiovascular cell therapy by forward programming pluripotent stem cells (PSCs) into early ventricular cardiomyocytes using Nkx2.5 transcription factor and ascorbic acid. Terminal maturation of PSC-derived cardiomyocytes in vitro remains a challenge.

Keywords:
Cardiovascular forward programmingNkx2.5PSCsVentricular subtype identity

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