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04:44
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
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Connective Tissue Disease-Associated Interstitial Lung Disease: Evaluation and Management
Danielle Antin-Ozerkis1, Monique Hinchcliff2
1Section of Pulmonary and Critical Care Medicine, Yale School of Medicine, PO Box 208057, New Haven, CT 06520-8057, USA.
Clinics in Chest Medicine
|August 5, 2019
Summary
Interstitial lung disease (ILD) is a serious complication in connective tissue disease patients. Early diagnosis and a multidisciplinary approach are key for managing this condition and improving outcomes.
Area of Science:
- Rheumatology
- Pulmonology
- Internal Medicine
Background:
- Interstitial lung disease (ILD) frequently complicates connective tissue diseases (CTD), significantly impacting patient morbidity and mortality.
- Radiographic findings in CTD patients necessitate exclusion of infection and drug toxicity.
- Immunosuppression is a common therapeutic strategy for CTD-ILD, despite limited supporting evidence from controlled trials.
Purpose of the Study:
- To review the current understanding and management of interstitial lung disease in the context of connective tissue disease.
- To highlight the importance of differential diagnosis and therapeutic considerations in CTD-ILD.
Main Methods:
- Literature review focusing on the diagnosis, treatment, and management of interstitial lung disease in patients with connective tissue disease.
- Synthesis of current clinical guidelines and evidence regarding immunosuppressive therapy and multidisciplinary care.
Main Results:
- Interstitial lung disease is a major cause of death in CTD patients.
- Excluding infection and drug toxicity is critical in the evaluation of radiographic abnormalities.
- Therapeutic decisions for CTD-ILD should consider disease severity and progression rate.
Conclusions:
- A comprehensive, multidisciplinary approach is essential for managing CTD-ILD, incorporating supportive and nonpharmacologic strategies alongside pharmacologic treatments.
- Careful assessment of disease activity and progression is crucial when initiating therapy.
Keywords:
Connective tissue diseaseImmunosuppressionInterstitial lung diseasePulmonary fibrosisRheumatoid arthritisSclerodermaSupportive careMore Related Videos
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