Age-related differences in the structural and effective connectivity of cognitive control: a combined fMRI and DTI

Thomas Hinault1, Kevin Larcher2, Louis Bherer3

  • 1Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD, USA; McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montréal, QC, Canada.

Neurobiology of Aging
|August 5, 2019
PubMed

Related Concept Videos

Arithmetic Mean01:08

Arithmetic Mean

The arithmetic mean is the most commonly used measure of the central tendency of a data set. It is defined as the sum of all the elements constituting the data set, divided by the total number of elements. It is sometimes loosely referred to as the “average.”
When all the values in a data set are not unique, the sum in the numerator can be calculated by multiplying each distinct value by its frequency.
Sometimes, the arithmetic mean of a sample can be affected by a few data points...
17.2K
Cognitive Dissonance01:38

Cognitive Dissonance

Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
36.8K
Phasor Arithmetics01:13

Phasor Arithmetics

Phasors and their corresponding sinusoids are interrelated, offering unique insights into the behavior of alternating current (AC) circuits. One way to understand this relationship is through the operations of differentiation and integration in both the time and phasor domains.
When the derivative of a sinusoid is taken in the time domain, it transforms into its corresponding phasor multiplied by j-omega (jω) in the phasor domain, where j is the imaginary unit, and ω is the angular...
774
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
191
Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
6.8K
Combined Effects of Drugs: Antagonism01:30

Combined Effects of Drugs: Antagonism

The combined effects of drugs can result in various interactions, of which an important type is antagonism. Antagonism is a mechanism where one drug inhibits or counteracts the effects of another drug. Antagonism can occur through various means, including receptor binding, allosteric modulation, functional interaction, chemical reactions, and pharmacokinetic processes.
The most common type is receptor antagonism, where one drug acts as an antagonist to block the effects of another drug by...
11.6K