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Comparison between IVF and GIFT using the GnRH agonist protocol.

E Cittadini1, R Palermo, V Agrifoglio

  • 1Istituto Materno-Infantile, Palermo.

Acta Europaea Fertilitatis
|January 1, 1988
PubMed
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The use of Buserelin in assisted reproductive technology cycles, such as Gamete Intrafallopian Transfer (GIFT) and In Vitro Fertilization (IVF), improved ovocyte quality and increased fertilization and pregnancy rates. This suggests pituitary temporary ablation is beneficial for IVF and GIFT protocols.

Area of Science:

  • Reproductive Endocrinology
  • Assisted Reproductive Technologies

Background:

  • Gonadotropin-releasing hormone (GnRH) agonists are utilized in stimulation protocols for GIFT and IVF/ET cycles.
  • Buserelin, a GnRH agonist, was investigated for its efficacy in these protocols.

Purpose of the Study:

  • To evaluate the effectiveness of Buserelin in GIFT and IVF/ET cycles.
  • To assess the impact of Buserelin on ovocyte yield, quality, fertilization, and pregnancy rates.

Main Methods:

  • Buserelin was administered nasally on day 21 of the cycle preceding stimulation.
  • Follicle-Stimulating Hormone (FSH) and/or Human Menopausal Gonadotropin (HMG) were administered from day 3 of the stimulation cycle.
  • 34 GIFT cycles and 40 IVF cycles were analyzed.

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Main Results:

  • Minor endogenous luteinizing hormone (LH) interferences were observed compared to control cycles.
  • Increased numbers of harvested ovocytes were noted.
  • Enhanced ovocyte quality, fertilization rates, and pregnancy rates were achieved.

Conclusions:

  • Buserelin administration in GIFT and IVF protocols led to improved outcomes.
  • Pituitary temporary ablation using GnRH agonists is recommended as a primary treatment for IVF and GIFT.