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Genetic mapping of the 21-hydroxylase locus: estimation of small recombination frequencies
C E Aston1, S L Sherman, N E Morton
1Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York.
American Journal of Human Genetics
|September 1, 1988
Abstract:
The locus for 21-hydroxylase (CA21HB) has been mapped to the interval between the HLA-B and HLA-DR loci on chromosome 6. Several methods of estimating genetic distance were used to determine whether CA21HB is closer to HLA-B or HLA-DR based on data collected on 157 families ascertained through a proband with the classical form of 21-hydroxylase deficiency (CA12Hd). The results were inconclusive but serve to highlight the limitations of present methods of estimating genetic distance when recombination frequencies are of the order of .005.