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Updated: Jan 21, 2026

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
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mGlu2/3 receptor antagonists

Shigeyuki Chaki1

  • 1Research Headquarters, Taisho Pharmaceutical Co., Ltd., Yoshino-cho, Saitama, Japan.

Advances in Pharmacology (San Diego, Calif.)
|August 6, 2019
PubMed
Summary

Metabotropic (mGlu) 2/3 receptor antagonists show promise for treating depression and anxiety. Their antidepressant effects, similar to ketamine, warrant further investigation as novel therapeutic agents.

Keywords:
AMPA receptorAntidepressantKetamineNeuroplasticitymGlu2/3 receptor antagonist

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