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Related Experiment Video

Updated: Jan 21, 2026

A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia

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Published on: February 3, 2023

Sequential multistenting protocol in biliary stenosis after liver transplantation: a prospective analysis.

Ilaria Tarantino¹, Michele Amata¹, Noemi Cicchese¹

¹Endoscopy Service, Department of Diagnostic and Therapeutic Services, IRCCS - ISMETT, Palermo, Italy.

|August 6, 2019

Summary

This summary is machine-generated.

This study shows a new sequential multistenting protocol is highly effective for treating liver transplant anastomotic stenosis, with a 98.9% success rate and low recurrence. The endoscopic retrograde cholangiography (ERC) method offers a promising, safe approach.

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Published on: June 14, 2024

Area of Science:

Hepatobiliary surgery
Gastroenterology
Transplantation medicine

Background:

Biliary complications are a significant cause of morbidity after liver transplantation.
Endoscopic retrograde cholangiography (ERC) is crucial for managing duct-to-duct anastomosis complications.
Previous retrospective studies suggested a sequential multistenting protocol without stent removal is effective.

Purpose of the Study:

To prospectively evaluate the clinical success, recurrence, and adverse event rates of a sequential multistenting protocol for anastomotic stenosis after liver transplantation.

Main Methods:

Prospective analysis of 87 patients with anastomotic stenosis post-liver transplantation from May 2012 to May 2018.
A sequential multistenting protocol using multiple plastic stents (10 Fr) placed during ERCs every 3 months for up to 1 year.
No stent removal or exchange was performed during the protocol.

Main Results:

High clinical success rate of 98.9% (86/87 patients), defined by stricture resolution and cholestasis normalization.
A low recurrence rate of 8.0% (7/87 patients) after a mean follow-up of 992.7 days.
An overall complication rate of 8.0% (7/87 patients) was observed.

Conclusions:

The sequential multistenting protocol demonstrates prospective efficacy and safety in managing post-transplant anastomotic stenosis.
This approach offers a viable alternative to traditional stent exchange methods.
A limitation is the absence of a direct comparative arm using the traditional approach.