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Updated: Jan 21, 2026

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
Published on: July 15, 2015
[Efficacy of conventional chemotherapy in a primary double-refractory IgM multiple myeloma.]
Vanessa Innao1, Alessandro Allegra1, Andrea Gaetano Allegra1
1Divisione di Ematologia, Dipartimento di Patologia Umana dell'Adulto e dell'Età Evolutiva "Gaetano Barresi", Università di Messina, Italia.
Abstract:
We report the case of a young man and good PS, diagnosed with a stage II A Durie-Salmon, II ISS and II Revised-ISS IgM kappa Multiple Myeloma. After refractoriety to the I and II-line induction therapies, including novel and novel novel agents, we decided to treat the patient with conventional high dose chemotherapy, with dexamethasone, cyclophosphamide, etoposide and cisplatin (DCEP), achieving a very good partial response (VGPR). Furthermore, we discuss histopathologic patterns, to make a correct differential diagnosis with others IgM-correlated disorders. Analyzing the literature, we demonstrated that more intensive therapy correlates with better therapeutic goals, therefore, empathizing that today IgM Multiple Myeloma is still a difficult pathological subtype to treat.
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