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Genetic association between mannose-binding lectin polymorphisms and viral hepatitis: a meta-analysis
Chunhua Qie1, Yamin Liu1, Ping Ma1
1Department of Laboratory Medicine, Tianjin Second People's Hospital, Tianjin 300192, China.
Pathogens and Disease
|August 6, 2019
Summary
Mannose-binding lectin (MBL) gene variations in the promoter and exon 1 regions are significantly linked to viral hepatitis susceptibility. These MBL polymorphisms may help identify individuals at higher risk for hepatitis B and C infections.
Area of Science:
- Immunogenetics
- Hepatology
- Molecular Epidemiology
Background:
- Mannose-binding lectin (MBL) plays a crucial role in innate immunity.
- Previous studies on MBL polymorphisms and viral hepatitis have yielded inconsistent results.
- A comprehensive meta-analysis is needed to clarify the association in a larger population.
Purpose of the Study:
- To investigate the association between mannose-binding lectin (MBL) gene polymorphisms and susceptibility to viral hepatitis.
- To conduct a meta-analysis of existing studies to provide a pooled analysis of MBL polymorphisms and viral hepatitis.
- To explore potential associations in specific viral hepatitis types like HBV and HCV.
Main Methods:
- Systematic literature search of major scientific databases (PubMed, Web of Science, Embase, CNKI).
- Meta-analysis of 27 eligible studies including 4840 cases and 5729 controls.
- Statistical analysis using Review Manager software to assess pooled effects and heterogeneity.
Main Results:
- Significant associations were found between MBL promoter (-211C/G) and exon 1 (codon 52, 54, 57) polymorphisms and viral hepatitis in the overall population.
- Subgroup analyses confirmed significant associations for MBL promoter polymorphism in Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) infections.
- No significant associations were detected for MBL exon 1 polymorphism in subgroup analyses for HBV and HCV.
Conclusions:
- MBL promoter and exon 1 polymorphisms are significantly associated with viral hepatitis.
- These MBL genetic variations may serve as biomarkers for identifying individuals with increased susceptibility to HBV and HCV.
- Further research could explore the functional implications of these polymorphisms in viral hepatitis pathogenesis.
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