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Updated: Jan 21, 2026

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
Published on: March 11, 2021
Radiation effective dose assessment of [51Mn]- and [52Mn]-chloride
Laura De Nardo1, Guillermina Ferro-Flores2, Cristina Bolzati3
1Department of Physics and Astronomy, University of Padova, Via Marzolo 8, Padova, 35131, Italy; INFN, Sezione di Padova, Via Marzolo 8, Padova, 35131, Italy.
Abstract:
In order to establish the potential of [51/52Mn]Cl2 as safe PET brain tracers, the radiation effective dose (ED) of [51Mn]- and [52Mn]-chloride has been assessed by using biokinetic models in anthropomorphic phantoms. Results showed that [52Mn]-chloride releases one hundred thirty times more radiation dose (ED = 1.35 mSv/MBq) than [51Mn]-chloride (ED = 1.02E-02 mSv/MBq). Although the maximum positron energy of 52Mn allows a PET image resolution similar to that of 18F, activities below 15 MBq should be administered.
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