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Updated: Jan 21, 2026

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Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
Published on: June 7, 2015
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RADIATION MACULOPATHY AFTER ONE-DAY SESSION STEREOTACTIC RADIOSURGERY IN PATIENTS WITH CILIARY BODY AND CHOROIDAL
Summary
Higher radiation doses to the macula are the primary cause of radiation maculopathy following uveal melanoma treatment. Early diagnosis and tumor proximity influence risk, and current treatments for radiation maculopathy are largely ineffective.
Area of Science:
- Ophthalmology
- Radiation Oncology
- Medical Physics
Background:
- Radiotherapy, specifically stereotactic radiosurgery, is a standard treatment for uveal melanoma.
- Radiation retinopathy, including maculopathy, is a serious complication of eye irradiation.
- Understanding risk factors for radiation maculopathy is crucial for preserving visual acuity.
Purpose of the Study:
- To determine the association between radiation dose and other variables with the development of radiation maculopathy.
- To analyze risk factors for radiation-induced maculopathy in uveal melanoma patients.
Main Methods:
- Retrospective analysis of 168 patients treated with stereotactic radiosurgery (2007-2016).
- Bivariate and multivariate analysis to assess the impact of radiation dose and other factors.
- Evaluation of tumor location and pre-treatment visual acuity as potential risk factors.
Main Results:
- The prevalence of radiation maculopathy was 29%, with a median onset of 16 months post-irradiation.
- Higher radiation doses to the macula (median 37 Gy) were significantly associated with maculopathy (p=0.0016).
- Postequatorial tumor location and better pre-treatment visual acuity were also significant risk factors.
Conclusions:
- Radiation dose to the macula is the key determinant of radiation-induced maculopathy.
- Tumor proximity to the macula indirectly increases radiation dose and risk.
- Current treatment options for radiation maculopathy show limited efficacy in improving visual acuity.
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