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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
984
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

926
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
548
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

651
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Inflammatory Response01:28

Inflammatory Response

16.1K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
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Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
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Inflammatory bowel disease: Looking beyond the tract.

Sana Chams1, Reina Badran2, Skye El Sayegh3

  • 11 Division of Geriatric Medicine, Beaumont Health, Royal Oak, MI, USA.

International Journal of Immunopathology and Pharmacology
|August 7, 2019
PubMed
Summary

Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, can affect organs beyond the gut. Early detection of these extraintestinal manifestations is crucial for preventing complications and cancer.

Keywords:
Crohn’s diseaseextraintestinal manifestationsinflammatory bowel diseasescreeningtreatmentulcerative colitis

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Area of Science:

  • Gastroenterology and Immunology

Background:

  • Inflammatory bowel disease (IBD) comprises Crohn's disease and ulcerative colitis, characterized by chronic gastrointestinal inflammation.
  • IBD is associated with a wide range of extraintestinal manifestations (EIMs) affecting multiple organ systems.
  • EIMs can significantly impact patient morbidity and quality of life.

Purpose of the Study:

  • To provide a comprehensive review of current knowledge regarding EIMs in IBD patients.
  • To discuss screening and surveillance strategies for EIMs in IBD.
  • To emphasize the importance of early diagnosis for preventing morbidity and potential cancer development.

Main Methods:

  • Systematic literature review of studies on IBD and EIMs.
  • Analysis of current guidelines for screening and surveillance of EIMs.
  • Synthesis of evidence on the impact of EIMs on disease progression and outcomes.

Main Results:

  • EIMs are common in IBD, affecting nearly every organ system.
  • Specific EIMs have varying prevalence and clinical significance.
  • Evidence supports targeted screening for certain EIMs based on risk factors.

Conclusions:

  • Understanding and monitoring EIMs is essential for comprehensive IBD management.
  • Implementing recommended screening and surveillance protocols can improve patient outcomes.
  • Timely diagnosis and management of EIMs are critical for reducing long-term complications and cancer risk.