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A Rat Orthotopic Renal Transplantation Model for Renal Allograft Rejection
Published on: February 2, 2022
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Increased circulating Tfh to Tfr ratio in chronic renal allograft dysfunction: a pilot study
1Department of Laboratory Medicine, West China Hospital, Sichuan University, No.37 Guoxue Xiang, Wuhou District, Chengdu, Sichuan, China.
BMC Immunology
|August 7, 2019
Summary
An imbalance in T follicular helper (Tfh) and T follicular regulatory (Tfr) cells is linked to chronic renal allograft dysfunction (CAD). Lower Tfr cells and a higher Tfh/Tfr ratio indicate increased risk in kidney transplant recipients.
Area of Science:
- Immunology
- Transplantation immunology
- Renal medicine
Background:
- T follicular helper (Tfh) cells are crucial for B cell differentiation and antibody production.
- T follicular regulatory (Tfr) cells modulate Tfh cell activity by inhibiting Tfh-B cell interactions.
Purpose of the Study:
- To investigate the role of circulating Tfh (cTfh) and Tfr (cTfr) cells in the development of chronic renal allograft dysfunction (CAD).
- To determine if the frequency of cTfh and cTfr cells, and serum CXCL13 levels, correlate with CAD in kidney transplant recipients.
Main Methods:
- Quantified the frequency of circulating Tfh (cTfh) and Tfr (cTfr) cells in 67 kidney transplant recipients (34 with CAD, 33 with stable function).
- Measured serum CXCL13 levels.
- Utilized linear and logistic regression analyses to assess the association of cTfh/cTfr ratio with estimated glomerular filtration rate (eGFR) and CAD.
Main Results:
- The CAD group exhibited significantly lower cTfr cell frequency (0.31% vs 0.68%) and a higher cTfh to cTfr ratio (55.4 vs 25.3) compared to the stable group.
- Serum CXCL13 levels were significantly elevated in the CAD group (30.4 vs 21.9 ng/ml).
- The cTfh to cTfr ratio was identified as an independent risk factor for reduced eGFR (P=0.012) and CAD (OR=1.043, P=0.031).
Conclusions:
- An imbalance between circulating Tfh and Tfr cells, characterized by decreased Tfr cells and an elevated Tfh/Tfr ratio, contributes to chronic renal allograft dysfunction.
- The cTfh/cTfr ratio serves as a significant independent risk factor for CAD development and progression.
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