Related Experiment Video

Updated: Jan 21, 2026

A RANKL-based Osteoclast Culture Assay of Mouse Bone Marrow to Investigate the Role of mTORC1 in Osteoclast Formation
09:37

A RANKL-based Osteoclast Culture Assay of Mouse Bone Marrow to Investigate the Role of mTORC1 in Osteoclast Formation

Published on: March 15, 2018

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Author Correction: Plumbagin attenuates cancer cell growth and osteoclast formation in the bone microenvironment of

Wei Yan1,2, Ting-Yu Wang3, Qi-Ming Fan1

  • 1Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.

Acta Pharmacologica Sinica
|August 7, 2019
PubMed

Insights

This correction provides an updated figure for plumbagin

Area of Science:

  • Pharmacology
  • Cancer Biology
  • Bone Microenvironment Research

Background:

  • Plumbagin exhibits anti-cancer properties.
  • Osteoclast formation is crucial in bone metastasis.
  • The bone microenvironment influences cancer progression.

Purpose of the Study:

  • To correct an error in a previously published figure.
  • To provide accurate visual data on plumbagin's effect on cancer cells in bone.
  • To ensure the integrity of scientific reporting.

Main Methods:

  • Correction of Figure 2a.
  • Re-evaluation of representative imaging data.
  • Ensuring accurate depiction of MDA-MB-231SArfp cell localization.

Main Results:

  • The corrected Figure 2a accurately represents the inhibitory effect of plumbagin.
  • The correction does not alter the original study's findings or conclusions.
  • Plumbagin treatment at 4 mg/kg for 1 week shows an effect on cancer cell localization.

Conclusions:

  • The scientific conclusions of the original article remain valid.
  • Accurate data representation is essential in scientific publications.
  • This amendment upholds the standards of scientific accuracy.

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