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Updated: Jan 21, 2026
Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies
Published on: October 7, 2021
Neuropathies associated with lymphoma†
Wolfgang Grisold1, Anna Grisold1, Christine Marosi1
1Department of Neurology, Kaiser Franz Josef Hospital, Kundratstraße 3, Vienna 1100, Austria (W.G.); Department of Neurology, Medical University of Vienna, Waehringer Gürtel 18-20, Vienna 1090, Austria (A.G.); Department of Oncology, Medical University of Vienna, Waehringer Gürtel 18-20, Vienna 1090, Austria (C.M.); Department of Radiology, Kaiser Franz Josef Hospital, Kundratstraße 3, Vienna 1100, Austria (S.M.); Department of Neurosciences, University of Padova, Via Giustiniani, 5, Padova 35128, Italy (C.B.).
Lymphoma can cause various neuropathies, including neurolymphomatosis (NL) and intravascular lymphoma (IL). Understanding these neurological complications is crucial for effective patient treatment and care.
Area of Science:
- Neurology
- Oncology
- Pathology
Background:
- Lymphoma frequently presents with diverse neurological manifestations.
- Peripheral nervous system (PNS) involvement in lymphoma requires accurate diagnosis for treatment.
- Neoplastic infiltration of nerves, termed neurolymphomatosis (NL), can affect cranial nerves, nerve roots, and peripheral nerves.
Purpose of the Study:
- To elucidate the varied neuropathies associated with lymphoma.
- To highlight the importance of understanding the etiology of neuropathy in lymphoma patients.
- To emphasize the diagnostic roles of imaging and tissue biopsy in neurolymphomatosis.
Main Methods:
- Review of literature on lymphoma-associated neuropathies.
- Discussion of diagnostic modalities including medical imaging and tissue diagnosis.
- Categorization of neuropathic presentations: mononeuropathy, multifocal neuropathy, plexopathies, and demyelinating neuropathies.
Main Results:
- Neurolymphomatosis (NL) involves neoplastic infiltration of the PNS.
- Intravascular lymphoma (IL) is a rare cause of PNS involvement, sometimes co-occurring with NL.
- Immune-mediated and paraneoplastic neuropathies are significant considerations in lymphoma patients.
Conclusions:
- Accurate diagnosis of lymphoma-induced neuropathy is essential for appropriate management.
- Knowledge of neurotoxic, radiotherapy, neoplastic, immune-mediated, and paraneoplastic effects is vital for patient care.
- Advances in imaging complement tissue diagnosis for peripheral nerve involvement in lymphoma.
