Multicomponent Approach to Hydantoins and Thiohydantoins Involving a Deep Eutectic Solvent.

Area of Science:

• Organic Chemistry
• Green Chemistry

Background:

• Hydantoins and thiohydantoins are important heterocyclic compounds with diverse biological activities.
• Efficient synthesis of these scaffolds is crucial for drug discovery and development.
• Traditional synthetic methods often involve harsh conditions or multiple steps.

Purpose of the Study:

• To develop an efficient and green synthetic strategy for diverse hydantoins and thiohydantoins.
• To utilize deep eutectic solvents as both reaction medium and reactant source.
• To provide a facile access to 5-amino-1,3-dialkyl-substituted hydantoins and thiohydantoins.

Main Methods:

• A three-component reaction strategy was employed.
• Deep eutectic solvent systems were utilized, with N,N'-dimethyl urea or N,N'-dimethyl thiourea and l-(+)-tartaric acid serving dual roles.
• The reaction conditions were optimized for yield and purity.

Main Results:

• The developed method efficiently synthesized a range of hydantoins and thiohydantoins.
• Good yields were obtained for the target 5-amino-1,3-dialkyl-substituted compounds.
• The use of deep eutectic solvent facilitated a greener and more efficient process.

Conclusions:

• This study presents an efficient and environmentally friendly synthetic route to hydantoins and thiohydantoins.
• The three-component reaction in deep eutectic solvent offers a practical approach for accessing valuable heterocyclic compounds.
• The methodology holds promise for scalable synthesis in medicinal chemistry.