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Updated: Jan 21, 2026

Preparation of Binary and Ternary Deep Eutectic Systems
Published on: October 31, 2019
Multicomponent Approach to Hydantoins and Thiohydantoins Involving a Deep Eutectic Solvent
Sambasivarao Kotha1, Naveen K Gupta1, Vikas R Aswar1
1Department of Chemistry, Indian Institute of Technology, Bombay, Powai, Mumbai, 400 076, India.
Abstract:
We report an efficient synthetic strategy to diverse hydantoins and thiohydantoins involving a three-component reaction with the aid of deep eutectic solvent. Here, N,N'-dimethyl urea and N,N'-dimethyl thiourea play a dual role as reactant and reaction medium along with l-(+)-tartaric acid. The three-component reaction provides an easy access to 5-amino-1,3-dialkyl-substituted hydantoins and thiohydantoins in good yields.
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