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The Hippo Signaling Pathway in Development and Disease
1Department of Physiology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390-9040, USA.
Developmental Cell
|August 7, 2019
Summary
The Hippo signaling pathway controls cell growth and organ size. Its dysregulation is linked to diseases like cancer, highlighting potential therapeutic targets.
Area of Science:
- Molecular Biology
- Cell Biology
- Physiology
Background:
- The Hippo signaling pathway is a crucial regulator of organ size and development.
- Dysregulation of this pathway is increasingly linked to human diseases, notably cancer.
Purpose of the Study:
- To provide an updated review of the Hippo signaling pathway.
- To discuss its roles in development, homeostasis, regeneration, and disease.
- To identify future research directions and therapeutic opportunities.
Main Methods:
- Literature review and synthesis of existing research on the Hippo pathway.
- Analysis of the pathway's involvement in various physiological processes and diseases.
- Identification of knowledge gaps and therapeutic strategies.
Main Results:
- The Hippo pathway plays fundamental roles in embryonic development and tissue homeostasis.
- Aberrant Hippo signaling contributes to tumorigenesis and other pathologies.
- Significant progress has been made, but key questions remain regarding pathway regulation and therapeutic application.
Conclusions:
- The Hippo pathway is a critical regulator with broad physiological functions.
- Understanding its role in disease opens avenues for novel therapeutic interventions.
- Further research is needed to fully elucidate the pathway's complexities and harness its therapeutic potential.
Keywords:
NF2TAZTEADYAPactomyosinadherens junctioncancercell polaritycytoskeletongrowth controlhippo signalingmechanotransductionmerlinneurofibromatosisoncogeneregenerationscallopedspectrintissue homeostasistumor suppressoryorkieMore Related Videos
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