Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glial Cells01:04

Glial Cells

93.3K
Overview
93.3K
Nervous Tissue: Glial Cells01:31

Nervous Tissue: Glial Cells

6.6K
Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial...
6.6K
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

522
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
522
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

868
Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
868
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

939
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
939
Acute Coronary Syndrome V: Nursing Management01:26

Acute Coronary Syndrome V: Nursing Management

283
Nursing Assessment:Nursing management of acute coronary syndrome (ACS) involves taking the patient's history, focusing on primary complaints such as chest pain, dyspnea, and excessive sweating (diaphoresis), as well as other symptoms like back or jaw pain, nausea, vomiting, palpitations, dizziness, and fatigue. The nurse also reviews the patient's history of cardiac events, risk factors such as hypertension, diabetes, smoking, family history, and current medications.In the objective assessment,...
283

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cellular and molecular mechanisms of astrocyte plasticity in learning and memory.

Trends in neurosciences·2026
Same author

Basic Science and Pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Novel Roles for the Ectoenzyme CD38 in the Maintenance of Transcriptional and Metabolic Homeostasis in Astrocytes.

Glia·2025
Same author

Meningeal vascular Aβ deposition associates with cerebral hypoperfusion and compensatory collateral remodeling.

Alzheimer's research & therapy·2025
Same author

Degradation of perineuronal nets in hippocampal CA2 explains the loss of social cognition memory in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Brain injury contributes to dopaminergic neurodegeneration, Lewy body pathology, and Parkinsonism preclinically with outcomes altered by T cell modulation.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Jan 21, 2026

An Electrochemiluminescence-Based Assay for MeCP2 Protein Variants
07:44

An Electrochemiluminescence-Based Assay for MeCP2 Protein Variants

Published on: May 22, 2020

28.3K

Glial Dysfunction in MeCP2 Deficiency Models: Implications for Rett Syndrome.

Uri Kahanovitch1, Kelsey C Patterson2, Raymundo Hernandez1,3

  • 1School of Neuroscience, Virginia Polytechnic and State University, Life Sciences I Building Room 212, 970 Washington St. SW, Blacksburg, VA 24061, USA.

International Journal of Molecular Sciences
|August 8, 2019
PubMed
Summary
This summary is machine-generated.

Rett syndrome, a neurodevelopmental disorder caused by Mecp2 gene mutations, involves more than just neurons. Glial cell dysfunction significantly contributes to the disease

Keywords:
astrocytesmicrogliaoligodendrocytes

More Related Videos

A Non-random Mouse Model for Pharmacological Reactivation of Mecp2 on the Inactive X Chromosome
08:27

A Non-random Mouse Model for Pharmacological Reactivation of Mecp2 on the Inactive X Chromosome

Published on: May 22, 2019

6.7K
An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
06:18

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Published on: August 13, 2019

12.8K

Related Experiment Videos

Last Updated: Jan 21, 2026

An Electrochemiluminescence-Based Assay for MeCP2 Protein Variants
07:44

An Electrochemiluminescence-Based Assay for MeCP2 Protein Variants

Published on: May 22, 2020

28.3K
A Non-random Mouse Model for Pharmacological Reactivation of Mecp2 on the Inactive X Chromosome
08:27

A Non-random Mouse Model for Pharmacological Reactivation of Mecp2 on the Inactive X Chromosome

Published on: May 22, 2019

6.7K
An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
06:18

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Published on: August 13, 2019

12.8K

Area of Science:

  • Neuroscience
  • Genetics
  • Developmental Biology

Background:

  • Rett syndrome (RTT) is a rare X-linked neurodevelopmental disorder primarily affecting females.
  • It is characterized by intellectual disability, motor deficits, and autistic features.
  • Mutations in the Mecp2 gene are the principal cause of RTT.

Purpose of the Study:

  • To review current evidence on the role of glial dysfunction in Rett syndrome.
  • To explore how glial cell abnormalities contribute to RTT pathogenesis.
  • To highlight the significance of glia in the RTT disease model.

Main Methods:

  • Literature review of preclinical and clinical studies on Rett syndrome.
  • Analysis of research focusing on glial cells (astrocytes, microglia, oligodendrocytes) in RTT models.
  • Synthesis of findings linking Mecp2 mutations to glial cell dysfunction.

Main Results:

  • Evidence indicates that glial cells, not just neurons, are critically involved in RTT.
  • Mecp2 deficiency in glia leads to altered neuronal function and synaptic deficits.
  • Specific glial cell types, including astrocytes and microglia, exhibit dysfunction in RTT.

Conclusions:

  • Glial dysfunction is a key factor in the etiology and progression of Rett syndrome.
  • Targeting glial pathways may offer novel therapeutic strategies for RTT.
  • Further research into glia-neuron interactions is crucial for understanding RTT.