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Updated: Jan 21, 2026
08:43
Chronic Ovine Model of Right Ventricular Failure and Functional Tricuspid Regurgitation
Published on: March 17, 2023
1.1K
Tricuspid annular plane systolic excursion is dependent on right ventricular volume in addition to function
Hang Zhao1,2, Yu Kang1, Jacob Pickle1
1Cardiovascular Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Echocardiography (Mount Kisco, N.Y.)
|August 8, 2019
Summary
Tricuspid annular plane systolic excursion (TAPSE) correlates with right ventricular ejection fraction (RVEF) but is also volume-dependent. Optimal TAPSE cut-off values for detecting RV dysfunction vary with RV volume.
Area of Science:
- Cardiology
- Echocardiography
- Cardiac Imaging
Background:
- Tricuspid annular plane systolic excursion (TAPSE) is a key echocardiographic measure of right ventricular (RV) function.
- The influence of RV preload on TAPSE has not been extensively studied.
Purpose of the Study:
- To investigate the relationship between TAPSE, RV ejection fraction (RVEF), and RV end-diastolic volume (RVEDV).
- To determine if RV volume affects the accuracy of TAPSE in diagnosing RV dysfunction.
Main Methods:
- Retrospective analysis of 380 cardiac magnetic resonance (CMR) exams.
- Measurement of RVEF and RVEDV using CMR.
- Correlation analysis of TAPSE with RVEF and RVEDVi.
- Validation of TAPSE cut-off values in an echocardiography cohort.
Main Results:
- TAPSE showed a strong linear correlation with RVEF (r=0.69, P<.001).
- TAPSE positively correlated with RVEDVi in patients with normal RVEF (r=0.208, P=.014).
- Optimal TAPSE cut-off for RV dysfunction varied by RV volume, with higher cut-offs for normal/mildly dilated RVs.
Conclusions:
- TAPSE is influenced by both RVEF and RV volume.
- The predictive accuracy and optimal cut-off for TAPSE in detecting RV dysfunction are dependent on RV volume.
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