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Chondroblastoma-like Osteosarcoma.

Youssef Al Hmada1, Anas Bernieh1, Robert W Morris1

  • 1From the Departments of Pathology (Drs Al Hmada, Bernieh, Lewin, and Allen), and Radiology (Dr Morris), University of Mississippi Medical Center, Jackson.

Archives of Pathology & Laboratory Medicine
|August 8, 2019
PubMed
Summary
This summary is machine-generated.

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Chondroblastoma-like osteosarcoma is a rare bone cancer variant. It requires consideration in differential diagnoses, particularly when radiographic findings suggest an aggressive lesion.

Area of Science:

  • Orthopedic Oncology
  • Skeletal Pathology

Background:

  • Chondroblastoma-like osteosarcoma is an exceptionally rare osteosarcoma variant.
  • Only 22 cases have been reported in English-language literature.
  • This tumor affects a wide age range and is slightly more common in males.

Purpose of the Study:

  • To review the clinical, radiographic, and histopathologic features of chondroblastoma-like osteosarcoma.

Main Methods:

  • Literature review of PubMed-published cases of chondroblastoma-like osteosarcoma.
  • Analysis of clinical, radiographic, and histopathologic data from reported cases.

Main Results:

  • Commonly affects the metatarsus and tibia, followed by the femur.
  • Often presents with malignant or concerning radiographic findings.

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  • Histology shows monotonous cells resembling chondroblastoma with abnormal osteoid deposition and bone destruction.

    • Conclusions:

    • Chondroblastoma-like osteosarcoma should be included in the differential diagnosis of chondroblastoma.
    • Consideration is especially important when radiologic findings indicate an aggressive lesion.