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PEDOT:PSS interfaces stabilised using a PEGylated crosslinker yield improved conductivity and biocompatibility
Matteo Solazzo1, Katarzyna Krukiewicz, Ainur Zhussupbekova
1Department of Mechanical and Manufacturing Engineering, Trinity College Dublin, The University of Dublin, Dublin, Ireland. monaghmi@tcd.ie.
Journal of Materials Chemistry. B
|August 8, 2019
Summary
Researchers developed a new method using poly(ethylene glycol)diglycidyl ether (PEGDE) to crosslink poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS). This enhances conductivity and biocompatibility for bioelectronic applications.
Area of Science:
- Materials Science
- Biomedical Engineering
- Polymer Chemistry
Background:
- Bioelectronic interfaces require materials that are biocompatible, stable, and electroconductive.
- Poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) is a conductive polymer with potential in biomedical research, but its solubility necessitates crosslinking.
- Poly(ethylene glycol) (PEG) derivatives are known for their anti-immunogenic properties and use in biomedical applications.
Purpose of the Study:
- To investigate poly(ethylene glycol)diglycidyl ether (PEGDE) as a crosslinker and conductive filler for PEDOT:PSS.
- To evaluate the impact of PEGDE crosslinking on the conductivity, stability, and biocompatibility of PEDOT:PSS films.
Main Methods:
- Synthesized PEDOT:PSS films crosslinked with varying concentrations of PEGDE.
- Utilized X-ray photoelectron spectroscopy (XPS) to analyze the crosslinking mechanism.
- Assessed film properties including aqueous dispersibility, electrical conductivity, hydrophilicity, cell viability, and cell spreading.
Main Results:
- XPS analysis suggests PEGDE crosslinks via its epoxy ring with PSS sulfonic groups, saturating at 3 w/v% PEGDE.
- PEGDE-crosslinked PEDOT:PSS films exhibited enhanced electrical conductivity and hydrophilicity.
- Films showed good cell viability and significantly increased cell spreading compared to uncrosslinked or GOPS-crosslinked films.
Conclusions:
- PEGDE serves as an effective crosslinker for PEDOT:PSS, improving its electroconductive and biocompatibility properties.
- The resulting highly hydrophilic 2D film substrate offers a next-generation formulation for bioengineering applications.
- This novel crosslinking method presents an improvement over traditional methods like glycidoxy propyltrimethoxysilane (GOPS).
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