Related Experiment Video
Updated: Jan 21, 2026

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy
Published on: January 12, 2019
Identification of Hub Genes in Duchenne Muscular Dystrophy: Evidence from Bioinformatic Analysis
Rupeng Zhang1, Leifeng Lv1, Wenrui Ban1
1Department of Orthopedics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Abstract:
The hub genes and signaling pathways associated with Duchenne muscular dystrophy (DMD) were predicted by bioinformatic methods to improve the therapeutic effect and quality of life of patients. Microarray data sets GSE465, GSE1004, and GSE1007 were downloaded from the Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) were identified by GEO2R, and function enrichment analyses were performed by DAVID. The protein-protein interaction (PPI) network was constructed and the module analysis was performed using STRING and Cytoscape. A total of 195 DEGs were identified. The enriched functions and pathways of the DEGs include extracellular exosome, focal adhesion, extracellular matrix (ECM), focal adhesion, PI3K-Akt signaling pathway, calcium signaling pathway, and ECM-receptor interaction. Fifteen hub genes were identified. DEGs and hub genes identified in the present study help us understand the molecular mechanisms underlying the pathogenesis and progression of DMD, and provide candidate targets for treatment of DMD.
Related Concept Videos
Satellite Stem Cells and Muscular Dystrophy
The Evidence for Evolution
The Muscular System
Gene Flow
Gene Families
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
Gene Therapy

