Related Experiment Video

Updated: Jan 21, 2026

Preparation of Herbal Medicine: Er-Xian Decoction and Er-Xian-containing Serum for In Vivo and In Vitro Experiments
08:07

Preparation of Herbal Medicine: Er-Xian Decoction and Er-Xian-containing Serum for In Vivo and In Vitro Experiments

Published on: May 31, 2017

11.6K

Medicine in the Fourth Dimension

Christopher R Cederroth1, Urs Albrecht2, Joseph Bass3

  • 1Experimental Audiology, Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden.

Cell Metabolism
|August 8, 2019
PubMed

Insights

Circadian biology, the study of daily rhythms, is crucial for optimizing drug effectiveness and reducing side effects. Integrating these biological rhythms into research can improve patient outcomes.

Area of Science:

  • Chronobiology
  • Pharmacology
  • Translational Medicine

Background:

  • Circadian biology's role is often overlooked in pre-clinical research and clinical translation.
  • Emerging evidence highlights circadian rhythms' impact on drug efficacy and toxicity.

Purpose of the Study:

  • To emphasize the critical role of circadian biology in drug development and clinical application.
  • To advocate for the integration of circadian factors into translational research.

Main Methods:

  • Review of current pre-clinical and translational research.
  • Analysis of emerging evidence on time-dependent drug effects.

Main Results:

  • Drug efficacy and toxicity are significantly influenced by the time of administration.
  • Target cell biology, governed by circadian rhythms, modulates organ response to drugs.

Conclusions:

  • Circadian factors are essential for improving drug efficacy and reducing toxicity.
  • Integrating circadian biology into translational research is necessary for optimizing therapeutic outcomes.
Keywords:
ADMEchronotherapycircadian biologyclock genesdrug metabolismtranslation

More Related Videos

Expansion of Two-dimension Electrospun Nanofiber Mats into Three-dimension Scaffolds06:14

Expansion of Two-dimension Electrospun Nanofiber Mats into Three-dimension Scaffolds

Published on: January 7, 2019

7.3K
Enema of Traditional Chinese Medicine for Patients with Severe Acute Pancreatitis06:05

Enema of Traditional Chinese Medicine for Patients with Severe Acute Pancreatitis

Published on: January 27, 2023

27.7K

Related Concept Videos

Support Reactions in Three Dimensions01:27

Support Reactions in Three Dimensions

Support reactions in three dimensions help maintain the stability and equilibrium of various structures and systems. These reactions prevent the system from translating and rotating, ensuring the design can withstand external forces and perform its intended function efficiently and safely. Some of the supports providing support reactions in three dimensions are discussed below:
Ball and Socket Joint is one of the supports allowing free rotation about any axis. This freedom of rotation is...
1.6K
Relative Velocity in One Dimension01:10

Relative Velocity in One Dimension

The understanding of the concept of reference frames is essential to discuss relative motion in one or more dimensions. When we say that an object has a certain velocity, we must state the velocity with respect to a given reference frame. In most examples, this reference frame has been Earth. For instance, if a statement reads that a person is sitting in a train moving at 10 m/s east, then it implies that the person on the train is moving relative to the surface of Earth at this velocity,...
9.7K
Relative Velocity in Two Dimensions01:11

Relative Velocity in Two Dimensions

Relative velocity is the velocity of an object as observed from a particular reference frame, or the velocity of one reference frame with respect to another reference frame. The concept of relative velocity can be used to describe motion in two dimensions. Consider a particle P and two reference frames S and S′. The position of the origin of S′ as measured in S is , the position of P as measured in S′ is , and the position of P as measured in S is , which can be evaluated by utilizing...
8.9K
Dimensions of Health and Illness01:21

Dimensions of Health and Illness

The factors influencing the health-illness continuum can be internal or external and may or may not be under conscious control. They are related to the following eight human dimensions, and each dimension is interrelated to one other.
10.7K
Equations of Equilibrium in Three Dimensions01:30

Equations of Equilibrium in Three Dimensions

When analyzing structures or systems at rest, it is necessary to ensure they are in equilibrium. This is where the vector and scalar equations of equilibrium come into play. These equations are crucial in ensuring a structure is stable and will not collapse or fall apart. The vector and scalar equations of equilibrium provide a framework for analyzing the forces acting on a body.
According to the vector equations of equilibrium, the vector sum of all the external forces acting on a body must...
1.8K
Structural Properties and Dimensions of Lumber01:21

Structural Properties and Dimensions of Lumber

Wood's structural properties derive from fibers aligned along the tree's length, contributing significantly to its mechanical strength. Wood exhibits up to twenty times greater tensile strength along these fibers compared to across them, and generally shows better performance under compression than tension. The length of fibers varies, with hardwoods having fibers around one twenty-fifth inch long and softwoods ranging from one-eighth to one-third inch.
The strength characteristics of...
383