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Angiotensin Receptor Blockers Effect on Serum Uric Acid-A Class Effect?
Elizabeth M Sutton Burke1, Tessa C Kelly1, Lindsey A Shoales1
1Pharmacy Practice and Administration, 242956Wegmans School of Pharmacy, St. John Fisher College, Rochester, NY, USA.
Angiotensin receptor blockers (ARBs) do not uniformly affect serum uric acid levels. Only losartan consistently lowers uric acid, making it a potential first-line choice for patients with hypertension and high uric acid.
Area of Science:
- Pharmacology
- Nephrology
- Cardiology
Background:
- Angiotensin receptor blockers (ARBs) are widely prescribed for hypertension.
- Serum uric acid levels are associated with cardiovascular and renal disease.
- The potential class effect of ARBs on serum uric acid requires clarification.
Purpose of the Study:
- To review existing literature and determine if a class effect exists for ARBs regarding serum uric acid levels.
- To identify specific ARBs that may influence serum uric acid.
Main Methods:
- A comprehensive literature search was conducted.
- Eight relevant articles were identified and included in the review.
Main Results:
- Candesartan and valsartan showed neutral or negative effects on serum uric acid.
- Azilsartan decreased serum uric acid, while eprosartan had no impact.
- Irbesartan had a neutral or positive effect, and losartan demonstrated a positive effect.
Conclusions:
- The reduction of serum uric acid is not a class effect of ARBs.
- Losartan is the only ARB with clear evidence of lowering serum uric acid.
- Losartan is recommended as a first-line agent for patients with hypertension and hyperuricemia, with irbesartan as an alternative.
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