Related Experiment Video
Updated: Jan 21, 2026

Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy
Published on: June 18, 2020
Retrieval of chronic hepatitis B patients in the Utrecht region in the Netherlands
M Dimmendaal1, P A M Kracht, S Dijkstra
1Department for Infectious Disease Control, Public Health Services Utrecht region (GGDrU), Zeist, the Netherlands.
Insights
Tracing lost to follow-up chronic hepatitis B (CHB) patients through past HBsAg tests and general practitioner collaboration can help re-engage individuals in care. This proactive approach aims to reduce the disease burden in the Netherlands.
Area of Science:
- Hepatology
- Public Health
- Patient Management
Background:
- Chronic hepatitis B (CHB) causes significant mortality in the Netherlands despite available treatments.
- An estimated 49,000 individuals in the Netherlands have CHB, with many lost to follow-up (LFU).
- Effective strategies are needed to re-integrate LFU CHB patients into healthcare systems.
Purpose of the Study:
- To identify and re-engage LFU CHB patients in the Utrecht province.
- To assess the feasibility of tracing LFU CHB patients through historical data and general practitioner (GP) involvement.
Main Methods:
- Retrospective review of HBsAg-positive tests (2001-2015) from four Utrecht hospitals.
- Collaboration with GPs to evaluate LFU CHB patients and gather data via questionnaires.
- Analysis of patient characteristics and reasons for non-evaluation.
Main Results:
- 2,242 CHB patients identified; 599 (27%) were eligible for retrieval.
- GP response rate was 49% (292 patients).
- 62 patients (10%) were evaluated, with 20 (3%) referred to hospital care.
Conclusions:
- Screening past HBsAg tests is an effective method for tracing LFU CHB patients.
- GPs demonstrated willingness to participate in patient retrieval efforts.
- This strategy shows potential for reducing the overall burden of CHB disease.
Background:
In the Netherlands, approximately 200 patients die annually from a chronic hepatitis B (CHB) infection, even though effective antiviral treatment is available. There are an estimated 49,000 Dutch CHB patients. Many of these patients have been lost to follow-up (LFU) over time. The study aimed to trace LFU CHB patients in the province of Utrecht and bring them back into care.
Methods:
Positive hepatitis B surface antigen (HBsAg) tests from 2001-2015 were collected from the four hospitals in the Utrecht province and linked to medical records. The general practitioners (GPs) were requested in writing to evaluate LFU CHB patients and to refer patients when needed. In addition, GPs were asked to fill out a questionnaire on the patients' characteristics and to indicate reasons for not being able to perform an evaluation.
Results:
A total of 2,242 chronic CHB patients were identified based on HBsAg-positive serology. After review of their medical records, 599 (27%) patients were eligible for retrieval. Of those, the GP response rate was 49% (n = 292) and 62 patients (10%) of the eligible CHB patients could be evaluated. Of these, 20 patients (3%) were referred to a hospital and 42 patients (7%) did not have an indication for referral.
Conclusion:
Lost to follow-up CHB patients can be traced through screening of past positive HBsAg tests. There was willingness among GPs to participate in the retrieval of CHB patients. This may contribute to the reduction of the CHB-related burden of disease.
Related Concept Videos
Retrieval
Recall involves accessing information without cues, such as during an essay test, where individuals must retrieve facts and concepts from memory unaided. Another example is remembering the name of a colleague...
ER Retrieval Pathway
The ER uses many checkpoints to prevent the entry of incorrectly folded or a resident protein as cargo onto a transport vesicle. These mechanisms...
IR Frequency Region: Fingerprint Region
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment
Hepatic Portal System
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
The Eukaryotic Promoter Region

