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Updated: Jan 21, 2026

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Strategies to Overcome Residual Risk During Statins Era

Kyoung Im Cho1, Jongwook Yu2, Toshio Hayashi3

  • 1Department of Cardiology, Kosin University Gospel Hospital.

Circulation Journal : Official Journal of the Japanese Circulation Society
|August 9, 2019
PubMed

Insights

Atherosclerosis management faces residual cardiovascular risk despite statin therapy. This review explores residual cholesterol and inflammation as key factors and proposes strategies to mitigate these risks in the statin era.

Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Pharmacology

Background:

  • Atherosclerosis is a major medical concern, linked to cardiovascular and endocrine disorders.
  • Low-density lipoprotein cholesterol (LDL-C) is a key risk factor for atherosclerosis.
  • Statins effectively lower LDL-C and improve cardiovascular outcomes, but residual risk remains.

Purpose of the Study:

  • To review the concept of residual risk in atherosclerosis management.
  • To discuss the roles of residual cholesterol and inflammation in cardiovascular events.
  • To propose strategies for overcoming residual risk in the era of statin therapy.

Main Methods:

  • Literature review of recent studies on atherosclerosis, statins, and residual risk.
  • Analysis of the impact of residual cholesterol and inflammation on cardiovascular events.
  • Synthesis of current evidence to suggest management strategies.

Main Results:

  • Intense statin therapy does not eliminate cardiovascular risk in all patients.
  • Residual cholesterol and inflammation are implicated as significant contributors to residual cardiovascular risk.
  • Current management strategies may not fully address these residual risk factors.

Conclusions:

  • Residual risk remains a critical challenge in managing patients with atherosclerosis on statin therapy.
  • Targeting residual cholesterol and inflammation is essential for comprehensive cardiovascular risk reduction.
  • Novel therapeutic strategies are needed to effectively manage residual risk and improve patient outcomes.

Keywords:
Cardiovascular diseasesCholesterolInflammationResidual riskStatins

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