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Asthma-I: Introduction

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

Asthma-III: Symptoms and Complications

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma

Asthma-IV: Diagnostic and Management

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

Asthma-IV: Nursing Management

Asthma-IV: Nursing Management

The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
First, in...

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Related Experiment Video

Updated: Jan 21, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Targeting eosinophils: severe asthma and beyond.

Marco Caminati^1,2, Francesco Menzella³, Lucia Guidolin²

¹Asthma Center and Allergy Unit, Verona University Hospital, Verona, Italy.

Drugs in Context

|August 9, 2019

Summary

Biologics targeting eosinophils and interleukin-5 (IL-5) are effective for severe asthma. These therapies show promise for other eosinophilic diseases, but tailored approaches are needed due to varying responses.

Keywords:

ABPA EGPA benralizumab eosinophilic esophagitis eosinophilic inflammation mepolizumab reslizumab severe asthma

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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

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Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Published on: May 30, 2020

Area of Science:

Immunology
Pulmonology
Rheumatology

Background:

Severe asthma often involves eosinophilic inflammation, a target for biologic therapies.
Interleukin-5 (IL-5) and its receptor are key in eosinophil development and activation.
Approved biologics like mepolizumab, reslizumab, and benralizumab target the IL-5 pathway.

Purpose of the Study:

To review the rationale and mechanisms of biologics targeting eosinophils and IL-5.
To discuss the efficacy and safety of these biologics in asthma and other eosinophilic conditions.
To highlight the need for tailored therapeutic strategies in non-asthma eosinophilic diseases.

Main Methods:

Literature review of clinical trials and case reports.
Analysis of mechanisms of action for IL-5 and IL-5 receptor targeting agents.
Synthesis of evidence regarding efficacy and safety in various eosinophilic diseases.

Main Results:

Anti-IL-5 biologics are approved and effective for severe eosinophilic asthma.
These biologics have been investigated for conditions including EGPA, allergic bronchopulmonary aspergillosis, and eosinophilic esophagitis.
Varied responses observed in non-asthma eosinophilic diseases suggest differences in pathophysiology and drug targeting.

Conclusions:

IL-5 targeting biologics offer a therapeutic option for various eosinophilic diseases beyond asthma.
Differences in eosinophil homing, target organs, and clinical features necessitate personalized treatment approaches.
Further research is crucial to optimize the use and expand the application of these biologics in non-asthma eosinophilic conditions.