Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Variation: Normal Distribution, Range, and Standard Deviation02:32

Variation: Normal Distribution, Range, and Standard Deviation

27.0K
In the field of psychology, there are several ways to organize measurements of a trait, feature, or characteristic (i.e., variables). Qualitative data, such as ethnicity, can be tabulated into a frequency count to provide information about the proportion, as well as the variety of groups in a sample or population. On the other hand, researchers can perform a wider set of calculations on quantitative data. The mean, mode, and median, for instance, are central tendency measures to identify a...
27.0K
Periodic Classification of the Elements04:00

Periodic Classification of the Elements

58.7K
The periodic table arranges atoms based on increasing atomic number so that elements with the same chemical properties recur periodically. When their electron configurations are added to the table, a periodic recurrence of similar electron configurations in the outer shells of these elements is observed. Because they are in the outer shells of an atom, valence electrons play the most important role in chemical reactions. The outer electrons have the highest energy of the electrons in an atom...
58.7K
Elements and Compounds01:27

Elements and Compounds

103.3K
Pure substances consist of only one type of matter. A pure substance can be an element or a compound. An element consists of only one type of atom, while a compound consists of two or more types of atoms held together by a chemical bond.
Elements
Elements are classified as atomic or molecular based on the nature of their basic units. They are unique forms of matter with specific chemical and physical properties that cannot break down into smaller substances by ordinary chemical reactions. There...
103.3K
Standard Deviation01:10

Standard Deviation

27.6K
The most commonly used measure of variation is the standard deviation. It is a numerical value measuring how far data values are from their mean. The standard deviation value is small when the data are concentrated close to the mean, exhibiting slight variation or spread. The standard deviation value is never negative, it is either positive or zero. The standard deviation is larger when the data values are more spread out from the mean, which means the data values are exhibiting more variation.
27.6K
Mean Absolute Deviation01:13

Mean Absolute Deviation

3.3K
The mean absolute deviation is also a measure of the variability of data in a sample. It is the absolute value of the average difference between the data values and the mean.
Let us consider a dataset containing the number of unsold cupcakes in five shops: 10, 15, 8, 7, and 10. Initially, calculate the sample mean. Then calculate the deviation, or the difference, between each data value and the mean. Next, the absolute values of these deviations are added and divided by the sample size to...
3.3K
The Periodic Table and Organismal Elements00:57

The Periodic Table and Organismal Elements

200.6K
Overview
200.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Systematic Expression and Localization Profiling of Piezo2 in Rodent Pancreatic Islets.

Nutrients·2026
Same author

From Antipsychotic to Antitumor Agent: Cariprazine Suppresses Glioblastoma via D2/D3-ARRB2 Axis Modulation.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

High-Performance Ink-Writable Polyurethane Elastomers Based on Crystalline PCL and Hindered Urea Bonds.

Macromolecular rapid communications·2026
Same author

M2 microglial exosomal miR-1949 ameliorates sepsis-associated encephalopathy through DKK1/Wnt/β-catenin-mediated microglial repolarization.

Archives of pharmacal research·2026
Same author

Biomimetic catalase-engineered black phosphorus nanosheets enhance photo-/radio-therapy for hepatocellular carcinoma.

Biomedical materials (Bristol, England)·2026
Same author

Generation of gamma photons carrying transverse orbital angular momentum driven by a spatiotemporal optical vortex laser.

Optics express·2026

Related Experiment Video

Updated: Jan 21, 2026

Determination of the Optimal Chromosomal Locations for a DNA Element in Escherichia coli Using a Novel Transposon-mediated Approach
11:12

Determination of the Optimal Chromosomal Locations for a DNA Element in Escherichia coli Using a Novel Transposon-mediated Approach

Published on: September 11, 2017

7.9K

Location deviations of DNA functional elements affected SNP mapping in the published databases and references.

Hewei Zheng1, Xueying Zhao2, Hong Wang3

  • 1Harbin Medical University and Wenzhou Medical University.

Briefings in Bioinformatics
|August 9, 2019
PubMed
Summary

Functional DNA element locations vary significantly across public databases, impacting precision medicine and genetic studies. Researchers must verify sequence alignments to ensure accurate data interpretation.

Keywords:
functional elementslocation deviationprecision medicinesequence alignment

More Related Videos

Amplification, Next-generation Sequencing, and Genomic DNA Mapping of Retroviral Integration Sites
09:31

Amplification, Next-generation Sequencing, and Genomic DNA Mapping of Retroviral Integration Sites

Published on: March 22, 2016

18.3K
Infinium Assay for Large-scale SNP Genotyping Applications
13:33

Infinium Assay for Large-scale SNP Genotyping Applications

Published on: November 19, 2013

39.8K

Related Experiment Videos

Last Updated: Jan 21, 2026

Determination of the Optimal Chromosomal Locations for a DNA Element in Escherichia coli Using a Novel Transposon-mediated Approach
11:12

Determination of the Optimal Chromosomal Locations for a DNA Element in Escherichia coli Using a Novel Transposon-mediated Approach

Published on: September 11, 2017

7.9K
Amplification, Next-generation Sequencing, and Genomic DNA Mapping of Retroviral Integration Sites
09:31

Amplification, Next-generation Sequencing, and Genomic DNA Mapping of Retroviral Integration Sites

Published on: March 22, 2016

18.3K
Infinium Assay for Large-scale SNP Genotyping Applications
13:33

Infinium Assay for Large-scale SNP Genotyping Applications

Published on: November 19, 2013

39.8K

Area of Science:

  • Genomics
  • Bioinformatics
  • Molecular Biology

Background:

  • Next-generation sequencing generates vast functional DNA element data.
  • Precision medicine necessitates accurate fine-mapping of risk loci.
  • Functional DNA elements are crucial for understanding genetic variations.

Purpose of the Study:

  • To investigate discrepancies in functional DNA element locations across public databases.
  • To assess the impact of these location variations on genetic studies, including genome-wide association studies (GWAS).

Main Methods:

  • Obtained human reference genome (GRCh38) and key DNA elements (genes, miRNAs, lncRNAs, SNP flanking sequences) from diverse repositories.
  • Realigned these elements to determine their precise genomic locations.
  • Compared element locations across different databases to quantify deviations.

Main Results:

  • Significant location deviations (5%-20%) were observed for DNA sequence elements, ranging from kilobase-pair to megabase-pair scales.
  • These discrepancies affected the identification of genes associated with risks in genome-wide association studies.
  • Location information for functional DNA elements is inconsistent among public databases.

Conclusions:

  • Functional DNA element location data varies across public databases, potentially compromising research accuracy.
  • Researchers should exercise caution when integrating data from multiple sources.
  • Performing pilot sequence alignments is recommended before conducting studies reliant on element locations.