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Thyroxine-binding globulin deficiency re-examined
1Endocrinology Research Group, Clinical Research Centre, Harrow, UK.
Clinical Endocrinology
|January 1, 1988
Abstract:
Seven sera, previously categorised as completely deficient in thyroxine-binding globulin (TBG) by an immunoelectrophoretic technique, were re-examined with a sensitive ELISA method. Only one of the sera was confirmed completely deficient by ELISA. The remaining six contained 0.08-0.19 mg/l. The protein was immunologically identical with 'normal' TBG, could bind to thyroxine and had the correct mobility in reverse-flow electrophoresis. Complete TBG deficiency may therefore be rare.