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Updated: Jan 21, 2026

Multiplexing Focused Ultrasound Stimulation with Fluorescence Microscopy
Published on: January 7, 2019
A nanoparticle enabled focused ultrasound-stimulated magnetic resonance imaging spotlight
Tian Deng1, Le Zhang, Holden H Wu
1Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, California 90095, USA. zink@chem.ucla.edu.
Abstract:
Periodic high-intensity focused ultrasound modulation of a nanoparticle generates reversible MRI T1 relaxivity changes at the 1.5 mm3 focal point causing periodic T1-weighted signal changes. Fourier analysis extracts signal changes at the modulation frequency, and a modulation enhancement map spotlights the precise region of interest by increasing contrast almost 100-fold.
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