Practical method for increasing optical purity of cis-verbenol
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Published on: May 10, 2017
Vitaly Kovalenko1, Aliaksei Krauchanka1, Konstantin Prokhorevich2
1Laboratory of Biotechnology and Biochemistry, Department of Natural Sciences, Belarusian State Pedagogical University, Minsk, Belarus.
Abstract:
R/S mixture of monoterpene alcohol cis-verbenol can be separated in preparative scale by its conversion into phthalic mono-ester and subsequent crystallization of its diastereomeric salts with (R)-α-methylbenzylamine and (S)-α-methylbenzylamine. Finally, basic methanolysis of the resolved phthalic mono-esters results (S)-cis-verbenol and (R)-cis-verbenol in high enantiomeric and diastereomeric purity.
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