Comparisons of psychophysical and neurophysiological studies of cochlear implants

This paper compares psychophysical and neural studies of electrical stimulation of the auditory nerve with the goal of evaluating the relevance of single-unit animal models for the development of cochlear prostheses for profoundly deaf humans. Comparative psychophysical studies with implanted deaf subjects indicate that animal models, at least nonhuman primates, provide a close match to humans, though this is not always true for acoustic stimulation of normal-hearing subjects. However, the human-animal comparisons, especially those involving electrical stimuli, need further study using more carefully matched conditions. Comparisons of psychophysical and neurophysiological thresholds for electrical stimulation in animals reveal consistently higher thresholds in the neural studies. A number of factors which may account for these differences are discussed. A partial resolution of the problem could result from conducting neurophysiological and behavioral studies in the same animal. Finally, comparison of psychophysical and neurophysiological studies of temporal encoding suggest that there may be more information encoded in the auditory nerve than is used by the system, at least for nonspectral frequency discrimination. This points to a need for further analysis of the processing of this information at higher levels in the auditory pathway.