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Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice
Published on: September 26, 2018
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Ghrelin-mediated pathway in Apolipoprotein-E deficient mice: a survival system
Rita Rezzani1,2, Caterina Franco1, Gaia Favero1
1Anatomy and Physiopathology Division, Department of Clinical and Experimental Sciences, University of Brescia Brescia, Italy.
American Journal of Translational Research
|August 10, 2019
Summary
Ghrelin hormone may protect kidneys by influencing the ghrelin/sirtuin 1 (SIRT1)/aquaporin (AQP) pathway in a mouse model of kidney disease and high cholesterol. This suggests ghrelin as a potential therapeutic target for renal injury.
Area of Science:
- Nephrology
- Endocrinology
- Metabolic Diseases
Background:
- Renal diseases disrupt metabolic pathways, leading to dyslipidemia and altered lipoprotein profiles.
- Apolipoprotein-E deficient (ApoE-/-) mice exhibit hypercholesterolemia and renal pathology, serving as a model for kidney injury.
- Ghrelin, a hormone found in the kidney, influences renal function and its levels increase with fasting, potentially interacting with the sirtuin 1 (SIRT1)/p53 pathway.
Purpose of the Study:
- To investigate the ghrelin/sirtuin 1 (SIRT1)/aquaporin (AQP) pathway in ApoE-/- mice.
- To clarify the role of this system in age-related renal diseases with or without comorbidities.
- To explore ghrelin as a potential therapeutic target for renal injury.
Main Methods:
- Utilized apolipoprotein-E deficient (ApoE-/-) mice as a model for hypercholesterolemia and renal pathology.
- Examined the ghrelin/sirtuin 1 (SIRT1)/aquaporin (AQP) pathway, focusing on AQP1 and AQP2.
- Assessed the system's role in aging-related renal diseases.
Main Results:
- The study evaluated the ghrelin/SIRT1/AQP1/AQP2 pathway in ApoE-/- mice.
- Results could highlight the significance of this system in renal diseases associated with aging.
- Findings may support ghrelin as a novel therapeutic target for kidney injury.
Conclusions:
- The ghrelin/SIRT1/AQP system plays a role in renal diseases.
- Ghrelin's interaction with SIRT1 and aquaporins warrants further investigation.
- Ghrelin emerges as a potential therapeutic avenue for mitigating renal injury.
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