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Brain Imaging and Impulse Control Disorders in Parkinson's Disease
Andreas-Antonios Roussakis1, Nicholas P Lao-Kaim1, Paola Piccini2
1Neurology Imaging Unit, Imperial College London - Hammersmith Hospital, 1st Floor, B-Block, Du Cane Road, London, W12 0NN, UK.
Current Neurology and Neuroscience Reports
|August 10, 2019
Summary
Dopamine receptor agonist therapy for Parkinson's disease (PD) can lead to impulse control disorders (ICD). Neuroimaging studies are exploring the brain mechanisms behind PD-related ICD to improve patient care.
Area of Science:
- Neuroscience
- Psychiatry
- Neurology
Background:
- Parkinson's disease (PD) presents with diverse symptoms, including psychiatric conditions.
- Current PD treatments, primarily dopaminergic drugs, are chronic and complex.
- Dopamine receptor agonists, while effective for motor symptoms, are linked to impulse control disorders (ICD).
Purpose of the Study:
- To review recent neuroimaging findings on the mechanisms of PD-related ICD.
- To discuss controversial studies and identify future research directions in PD-related ICD.
Main Methods:
- Review of key neuroimaging studies in Parkinson's disease with impulse control disorders.
- Analysis of research focused on the reward network and its role in PD-related ICD.
Main Results:
- Neuroimaging studies provide insights into PD-related ICD mechanisms, but findings are not conclusive.
- Research highlights the involvement of reward network structures in the development of ICD in PD patients.
Conclusions:
- Understanding the neurobiological underpinnings of PD-related ICD is crucial for managing psychiatric comorbidities.
- Further neuroimaging research is needed to clarify controversial findings and guide therapeutic strategies for ICD in Parkinson's disease.