Related Experiment Video
Updated: Jan 21, 2026
07:20
Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
Published on: January 28, 2014
37.2K
Clinicopathological features and survival for gallbladder NEN: a population-based study
Dong Cen1,2, Hui Liu1, Zhe Wan1,2
1Key Laboratory of Laparoscopic Technology of Zhejiang Province, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Endocrine Connections
|August 10, 2019
Summary
Gallbladder neuroendocrine neoplasms (GB-NEN) survival is impacted by age, marital status, tumor size, and stage. Gallbladder surgery improves outcomes, but lymph node resection offers no additional benefit.
Area of Science:
- Oncology
- Gastroenterology
- Epidemiology
Background:
- Gallbladder neuroendocrine neoplasms (GB-NEN) are rare, comprising 0.5% of all neuroendocrine neoplasms.
- Limited understanding of GB-NEN necessitates further clinicopathological and survival research.
Purpose of the Study:
- To investigate the clinicopathology and survival of GB-NEN patients.
- To identify prognostic factors influencing overall and cancer-specific survival in GB-NEN.
Main Methods:
- Analysis of 248 GB-NEN patients diagnosed between 2004-2015 from the SEER database.
- Kaplan-Meier curves for survival time analysis.
- Multivariate Cox proportional hazard models to determine independent predictors of survival.
Main Results:
- Majority of patients were women (67.3%), white (77%), and married (61.7%).
- Common tumor characteristics included <2 cm size (31.0%), G3 stage (25.8%), and distant SEER stage (41.1%).
- Gallbladder surgery significantly improved survival (P < 0.001), while combined surgery and lymphadenectomy showed no added benefit. Older age, unmarried status, large tumor size (>5 cm), and distant SEER stage predicted poorer survival.
Conclusions:
- Age, marital status, tumor size, and SEER stage are significant predictors of GB-NEN patient survival.
- Gallbladder surgery is associated with improved survival outcomes.
- Combined gallbladder surgery and lymphadenectomy do not enhance survival compared to surgery alone.
Related Concept Videos
01:17Gallbladder
2.0K
The gallbladder is a small, pear-shaped organ that plays a crucial role in our digestive system. Measuring about 10 cm in length, it is comparable in size to a kiwi fruit and is located in a hollow area on the lower surface of the liver. The gallbladder's primary function is to store and concentrate bile, a fluid produced by the liver that aids in digestion.
The gallbladder's anatomy consists of three regions: the fundus, body, and neck. Extending from the neck, the cystic duct joins...
The gallbladder's anatomy consists of three regions: the fundus, body, and neck. Extending from the neck, the cystic duct joins...
2.0K
01:26Diseases of the Liver and Gallbladder
1.9K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
1.9K
02:04Conservation of Small Populations
16.7K
Small population sizes put a species at extreme risk of extinction due to a lack of variation, and a consequent decrease in adaptability. This weakens the chances of survival under pressures such as climate change, competition from other species, or new diseases. Large populations are more likely to survive pressures such as these, as such populations are more likely to harbor individuals that have genetic variants that are adaptive under new stresses. Small populations are much less...
16.7K
01:25What is Population Genetics?
64.5K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
64.5K
01:19Survival Tree
393
Survival trees are a non-parametric method used in survival analysis to model the relationship between a set of covariates and the time until an event of interest occurs, often referred to as the "time-to-event" or "survival time." This method is particularly useful when dealing with censored data, where the event has not occurred for some individuals by the end of the study period, or when the exact time of the event is unknown.
Building a Survival Tree
Constructing a...
Building a Survival Tree
Constructing a...
393
01:18Survival Curves
664
Survival curves are graphical representations that depict the survival experience of a population over time, offering an intuitive way to track the proportion of individuals who remain event-free at each time point. These curves are widely used in fields such as medicine, public health, and reliability engineering to visualize and compare survival probabilities across different groups or conditions.
The Kaplan-Meier estimator is the most common method for constructing survival curves. This...
The Kaplan-Meier estimator is the most common method for constructing survival curves. This...
664