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ANNIVERSARY REVIEW: Octreotide, 40 years later
Steven W J Lamberts1, Leo J Hofland1
1Division of Endocrinology, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
European Journal of Endocrinology
|August 10, 2019
Summary
Octreotide is a long-standing treatment for acromegaly and GEP-NETs. This review covers its 40-year clinical history and the use of its radiolabeled forms.
Area of Science:
- Endocrinology
- Nuclear Medicine
Background:
- Octreotide, a somatostatin analog, has been a cornerstone therapy for decades.
- Its efficacy in treating acromegaly and gastroenteropancreatic neuroendocrine tumors (GEP-NETs) is well-established.
Observation:
- Despite its long history, significant therapeutic alternatives have emerged.
- This review examines the extensive clinical application of octreotide over 40 years.
Findings:
- The review highlights the enduring role of octreotide in managing specific endocrine disorders.
- It also explores the evolving use of radiolabeled octreotide analogs in diagnosis and therapy.
Implications:
- Understanding octreotide's long-term clinical journey provides insights into sustained therapeutic value.
- The integration of radiolabeled forms signifies advancements in personalized medicine for neuroendocrine tumors.
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