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AMH as the primary marker for fertility
Didier Dewailly1,2, Joop Laven3
1INSERM, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre, U1172, Lille, France.
European Journal of Endocrinology
|August 10, 2019
Summary
Anti-Müllerian hormone (AMH) is a reliable marker for ovarian reserve and useful in fertility treatments. While not predicting pregnancy, AMH aids in managing infertility, especially in specific patient groups.
Area of Science:
- Reproductive Endocrinology
- Gynecology
- Infertility Research
Background:
- Anti-Müllerian hormone (AMH) is produced by granulosa cells in growing ovarian follicles.
- AMH measurement correlates with antral follicle count, serving as a key indicator of ovarian reserve.
- AMH levels exhibit high reproducibility with minimal variation across menstrual cycles.
Purpose of the Study:
- To evaluate the utility of AMH as a marker in female reproductive health.
- To assess the predictive value of AMH for fertility and its applications in various clinical scenarios.
- To determine the role of AMH in assisted reproductive technologies and monitoring specific patient populations.
Main Methods:
- Review of existing literature on AMH measurement and its clinical applications.
- Analysis of AMH correlation with ovarian reserve markers like antral follicle count.
- Evaluation of AMH's role in predicting fertility outcomes and guiding treatment strategies.
Main Results:
- AMH is a quantitative reflection of ovarian reserve but does not assess oocyte or embryo quality.
- AMH serves as an indirect marker for remaining fertile years in women at risk of premature ovarian failure or with PCOS.
- AMH is valuable in assisted reproductive technology for selecting techniques, stimulation protocols, and gonadotropin dosage.
Conclusions:
- AMH is a valuable tool in managing female infertility, particularly in assisted reproduction and specific patient groups.
- AMH is informative for monitoring cancer patients undergoing gonadotoxic treatments or ovarian surgeries.
- Despite not being a direct pregnancy predictor, AMH significantly contributes to the clinical management of female reproductive health.
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