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Generation and Characterization of Human Induced Pluripotent Stem Cell-derived Astrocytes Lacking Fragile X Messenger Ribonucleoprotein
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Modeling Neurological Disorders with Human Pluripotent Stem Cell-Derived Astrocytes
Mika Suga1,2, Takayuki Kondo1,2,3, Haruhisa Inoue4,5,6
1iPSC-based Drug Discovery and Development Team, RIKEN BioResource Research Center (BRC), Kyoto 619-0237, Japan.
International Journal of Molecular Sciences
|August 11, 2019
Summary
Human induced pluripotent stem cell (iPSC)-derived astrocytes offer insights into neurological disorders. This review examines iPSC-based models for studying astrocyte roles in human brain diseases.
Area of Science:
- Neuroscience
- Stem Cell Biology
- Genetics
Background:
- Astrocytes are crucial glial cells in the central nervous system.
- Astrocytes play significant roles in the pathogenesis of various neurological disorders.
- Understanding astrocyte function is key to developing effective treatments for brain diseases.
Purpose of the Study:
- To review human induced pluripotent stem cell (iPSC)-based models for neurological disorders.
- To explore the utility of iPSC-derived astrocytes in disease modeling.
- To discuss the strengths and limitations of current iPSC-based astrocyte models.
Main Methods:
- Literature review of studies utilizing human iPSC-derived astrocytes for neurological disease modeling.
- Analysis of different iPSC reprogramming and astrocyte differentiation strategies.
- Comparative assessment of iPSC-based models for various neurological conditions.
Main Results:
- Human iPSC-derived astrocytes can recapitulate key features of human astrocytes.
- iPSC models allow for the study of astrocyte-specific contributions to neurological diseases.
- Various iPSC-based models show promise in disease research, each with unique advantages.
Conclusions:
- Human iPSC-derived astrocytes represent a powerful tool for investigating neurological disorders.
- iPSC technology facilitates the development of patient-specific disease models.
- Further refinement of iPSC-based astrocyte models will enhance their application in translational research.
Keywords:
astrocytesdisease modelinggliahuman neurological disordersiPSCinduced pluripotent stem cellsMore Related Videos
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