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The Ras Gene02:38

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The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
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The general state of stress within a material can be accurately depicted using a stress tensor. This tensor encapsulates the internal forces distributed within a material subjected to external forces or deformations.
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Related Experiment Video

Updated: Jan 21, 2026

Detection of Signaling Effector-Complexes Downstream of BMP4 Using in situ PLA, a Proximity Ligation Assay
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Ras Downstream Effector GGCT Alleviates Oncogenic Stress.

Zaoke He1, Shixiang Wang1, Yuanyuan Shao2

  • 1School of Life Science and Technology, ShanghaiTech University, Shanghai 201203, China; Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China; University of Chinese Academy of Sciences, Beijing, China.

Iscience
|August 11, 2019
PubMed
Summary

This study reveals a new metabolic pathway involving GGCT that helps cancer cells manage stress. This finding identifies GGCT as a potential therapeutic target for specific cancer treatments.

Keywords:
Biological SciencesCancerCell Biology

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Area of Science:

  • Cellular biology
  • Cancer research
  • Metabolism

Background:

  • Cellular stress is a hallmark of oncogenic transformation.
  • The mechanisms by which cells adapt to and overcome this stress remain incompletely understood.
  • Understanding these adaptive pathways is crucial for developing effective cancer therapies.

Purpose of the Study:

  • To identify novel pathways involved in alleviating oncogenic stress.
  • To investigate the role of GGCT in oncogenic transformation.
  • To explore GGCT as a potential cancer-specific therapeutic target.

Main Methods:

  • Investigated the GGCT-regulated glutathione (GSH)-reactive oxygen species (ROS) metabolic pathway.
  • Identified GGCT as a target of oncogenic Ras.
  • Utilized the LSL-Kras G12D mouse model for in vivo studies.

Main Results:

  • GGCT is required for oncogenic Ras-induced cell proliferation, transformation, and lung cancer formation.
  • GGCT deficiency does not impair normal mouse development.
  • Amplification of the GGCT locus supports its oncogenic role.

Conclusions:

  • GGCT plays a significant role in oncogenic stress adaptation and cancer progression.
  • The identified GGCT-regulated GSH-ROS pathway is a novel mechanism for stress alleviation.
  • GGCT represents a promising cancer-specific therapeutic target.