Related Experiment Video
Updated: Aug 7, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Relationship between monocytosis and T-lmphocyte function in human cancer
Cancer patients show higher monocyte counts in blood cell suspensions. This monocytosis correlates with suppressed T-lymphocyte function, indicating a potential link between immune cell imbalance and cancer progression.
Area of Science:
- Immunology
- Oncology
- Cell Biology
Background:
- Monocytes play a crucial role in immune responses.
- Altered immune cell populations are observed in cancer patients.
- The relationship between monocyte levels and T-lymphocyte function in cancer requires further investigation.
Purpose of the Study:
- To quantify monocyte numbers in peripheral blood mononuclear cell suspensions from cancer patients.
- To investigate the correlation between monocyte counts and in vitro T-lymphocyte function in cancer patients.
Main Methods:
- Mononuclear cells were isolated from peripheral blood of cancer patients and normal individuals.
- Monocyte quantification was performed using morphology and confirmed by phagocytosis assays.
- In vitro T-lymphocyte function was assessed by response to phytohemagglutinin.
Main Results:
- Cancer patients exhibited significantly higher monocyte counts (monocytosis) compared to normal individuals (P <= 0.01).
- Cancer patients with suppressed T-lymphocyte responses showed markedly higher monocyte numbers (47 +/- 11) than those with normal responses (29 +/- 9) (P <= 0.01).
- A strong positive correlation was observed between elevated monocyte levels and impaired T-lymphocyte function.
Conclusions:
- Peripheral blood mononuclear cell suspensions from cancer patients demonstrate significant monocytosis.
- Monocytosis in cancer patients is strongly associated with suppressed in vitro T-lymphocyte function.
- These findings suggest a potential role for monocyte-T-lymphocyte interactions in cancer-related immune dysregulation.
More Related Videos
10:59Conditional Knockdown of Gene Expression in Cancer Cell Lines to Study the Recruitment of Monocytes/Macrophages to the Tumor Microenvironment
Published on: November 23, 2017
09:04Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
Related Concept Videos
Cancer
What is Cancer?
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
Differentiation of Common Myeloid Progenitor Cells
Disorders of Leukocytes
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
T Cell Activation and Clonal Selection
Naive T cells that have not yet encountered an antigen express two primary CD...
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...