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Thyroid function and bipolar affective disorder.

R T Joffe1, S Kutcher, C MacDonald

  • 1Department of Psychiatry, St. Michael's Hospital, Toronto, Ont., Canada.

Psychiatry Research
|August 1, 1988
PubMed
Summary
This summary is machine-generated.

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Lithium treatment for bipolar disorder can affect thyroid function, with 19% of patients developing hypothyroidism. Female sex and longer lithium use were linked to these thyroid issues.

Area of Science:

  • Endocrinology
  • Psychiatry
  • Pharmacology

Background:

  • Bipolar affective disorder (BPAD) is a chronic mental health condition.
  • Lithium carbonate is a common mood stabilizer for BPAD.
  • Long-term lithium use may impact thyroid function.

Purpose of the Study:

  • To evaluate thyroid function in patients with BPAD on lithium carbonate.
  • To identify factors associated with lithium-induced thyroid dysfunction.

Main Methods:

  • Assessed thyroid function tests in 42 BPAD patients.
  • Patients received lithium carbonate for at least 3 months.
  • Correlated thyroid abnormalities with sex, illness course, and treatment duration.

Main Results:

Related Experiment Videos

  • 19% (8/42) of patients showed subclinical hypothyroidism or required thyroid replacement.
  • Thyroid dysfunction was associated with female sex.
  • Thyroid abnormalities correlated with longer lithium treatment duration.
  • No association found with rapid-cycling BPAD.

Conclusions:

  • Lithium carbonate treatment is associated with thyroid dysfunction in a significant minority of BPAD patients.
  • Female patients and those on longer lithium treatment are at higher risk.
  • Monitoring thyroid function is crucial for patients with BPAD on lithium therapy.