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[Malnutrition and chronic obstructive bronchopathies].

B Aguilaniu1

  • 1Service de Pneumologie, CHURG, Grenoble.

Revue Des Maladies Respiratoires
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

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Nutrition significantly impacts chronic airflow obstruction (CAO), with protein-energy malnutrition (PEM) affecting 30-50% of patients. Understanding this relationship is crucial for preventing and treating wasting in CAO.

Area of Science:

  • Respiratory Medicine
  • Nutritional Science
  • Biochemistry

Context:

  • Chronic airflow obstruction (CAO) is associated with a high prevalence (30-50%) of protein-energy malnutrition (PEM).
  • PEM in CAO is linked to hypermetabolism (HMB) and increased respiratory muscle workload, impairing respiratory muscle function.
  • Animal models show PEM can induce pulmonary emphysema and surfactant synthesis reduction, linked to altered protein synthesis and lysyl-oxydase activity.

Purpose:

  • To explore the intricate relationship between nutrition and the respiratory system in the context of chronic airflow obstruction.
  • To elucidate the physiological mechanisms underlying wasting in CAO, including hypermetabolism and its impact on respiratory muscles.
  • To highlight the pharmacological roles of nutrients, such as lipids and amino acids, in managing respiratory conditions.

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Summary:

  • Hypermetabolism in CAO is not offset by increased intake, leading to muscle wasting and impaired respiratory muscle efficiency.
  • Nutrients possess pharmacological properties: lipids modulate inflammation and smooth muscle activity, while amino acids influence ventilation and chemosensitivity.
  • Nutritional interventions, including amino acid perfusion and considering meal timing for oxygenation, are vital for managing CAO and preventing wasting.

Impact:

  • Provides a deeper understanding of malnutrition's role in CAO pathophysiology.
  • Suggests nutritional strategies as a key component in the preventive and therapeutic management of CAO.
  • Emphasizes the need to integrate nutritional support with respiratory care for improved patient outcomes.