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Micro-Pillar Integrated Dissolving Microneedles for Enhanced Transdermal Drug Delivery
Seunghee Lee1, Shayan Fakhraei Lahiji1, Jeesu Jang1
1Department of Biotechnology, Building 123, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea.
Pharmaceutics
|August 14, 2019
Summary
Patchless dissolving microneedle (DMN) systems enhance transdermal drug delivery. These novel micro-pillar integrated DMNs show improved drug delivery efficiency and skin penetration accuracy compared to traditional DMN patches.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Dermatology
Background:
- Traditional dissolving microneedle (DMN) patches face challenges with skin elasticity, leading to incomplete insertion and inaccurate drug delivery.
- Adhesive materials in DMN patches can cause skin irritation, inflammation, and redness, limiting their clinical applicability.
Purpose of the Study:
- To develop and evaluate a novel patchless, micro-pillar integrated DMN (P-DMN) system for enhanced transdermal drug delivery.
- To compare the drug delivery efficiency and skin penetration accuracy of P-DMNs against traditional DMN patches.
Main Methods:
- Fabrication of P-DMNs using hyaluronic acid and polymethyl methacrylate micro-pillars (300 μm height, 500 μm base diameter).
- Evaluation of transdermal delivery efficiency using a drug surrogate.
- Assessment of skin penetration accuracy of encapsulated drugs.
Main Results:
- P-DMNs demonstrated significantly improved drug delivery efficiency (91.83% ± 7.75%) compared to traditional DMNs (64.86% ± 8.17%).
- P-DMNs achieved a remarkable skin penetration accuracy rate (97.78% ± 2.22%), substantially higher than traditional DMNs (44.44% ± 7.85%).
Conclusions:
- The patchless micro-pillar integrated DMN (P-DMN) system offers a simple fabrication method and superior transdermal drug delivery performance.
- P-DMNs represent a highly accurate and efficient platform for delivering various micro- and macro-biomolecules transdermally, overcoming limitations of conventional DMN patches.
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