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Effects of newly introduced antidiabetic drugs on autophagy

Milad Ashrafizadeh1, Habib Yaribeygi2, Stephen L Atkin3

  • 1Department of Basic Science, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.

Diabetes & Metabolic Syndrome
|August 14, 2019
PubMed

Insights

New antidiabetic drugs, including SGLT2 inhibitors and GLP-1 receptor agonists, modulate autophagy. This review explores how these therapies impact cellular processes crucial for managing diabetes mellitus.

Area of Science:

  • Endocrinology
  • Metabolic Disorders
  • Cellular Biology

Background:

  • Diabetes mellitus is a chronic metabolic disorder with complex pathophysiology, increasing with age.
  • Newer antidiabetic agents like SGLT2 inhibitors (SGLT2i) and GLP-1 receptor agonists (GLP-1RA) offer novel therapeutic mechanisms.
  • Autophagy, a cellular degradation process, plays a critical role in maintaining homeostasis and is increasingly recognized in diabetes.

Purpose of the Study:

  • To review the modulatory effects of SGLT2i, DPP-4 inhibitors, and GLP-1RA on the autophagy process in diabetes.
  • To elucidate the impact of these novel antidiabetic drugs on cellular mechanisms relevant to diabetes management.

Main Methods:

  • Literature review of studies investigating the effects of SGLT2i, DPP-4 inhibitors, and GLP-1RA on autophagy.
  • Analysis of the distinct mechanisms of action for each drug class.

Main Results:

  • SGLT2i, DPP-4 inhibitors, and GLP-1RA demonstrate efficacy in diabetes management without inherent hypoglycemia risk.
  • These drugs exhibit modulatory effects on autophagy, influencing cellular survival and homeostasis.
  • The specific impact on autophagy varies depending on the drug class and its mechanism.

Conclusions:

  • Novel antidiabetic drugs, including SGLT2i and GLP-1RA, interact with the autophagy pathway.
  • Understanding these drug-autophagy interactions may offer new insights into diabetes treatment and cellular health.
  • Further research is warranted to fully explore the therapeutic potential of targeting autophagy in diabetes management.
Keywords:
AutophagyDPP-4Diabetes mellitusGRP-1SGLT

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