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Updated: Jan 21, 2026

A Rat Model of EcoHIV Brain Infection
Published on: January 21, 2021
Isavuconazole Diffusion in Infected Human Brain
Claire Rouzaud1, Vincent Jullien2, Anne Herbrecht3
1Necker-Enfants Malades University Hospital, Department of Infectious Diseases and Tropical Medicine, Centre d'Infectiologie Necker-Pasteur, Institut Imagine, AP-HP, Paris University, Paris, France.
Abstract:
We report the cases of a 39-year-old woman with chronic lymphocytic leukemia and a 21-year-old man with chronic granulomatous disease treated for cerebral aspergillosis. The patients required radical surgery for infection progression despite adequate isavuconazole plasma concentration or neurological complication. We thus decided to measure the brain isavuconazole concentration. These results suggest that the concentrations of isavuconazole obtained in the infected brain tissue clearly differ from those obtained in the normal brain tissue and the cerebrospinal fluid.
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