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An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
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[Candidemia: the most frequent invasive fungal infection in France]

Simon Galmiche1, Fanny Lanternier2,3, Marie Desnos-Ollivier2

  • 1Centre d'épidémiologie clinique, institut Lady Davis, Hôpital général juif et Département d'épidémiologie, biostatistiques et santé au travail, Université McGill, Montréal, Canada.

La Revue Du Praticien
|July 13, 2026
PubMed

Insights

Candidemia, a frequent invasive fungal infection in France, often presents as sepsis, particularly in hospitalized patients. Early diagnosis and appropriate antifungal treatment are crucial for improving outcomes in this serious condition.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Public Health

Background:

  • Candidemia is the most prevalent invasive fungal infection in France.
  • It primarily occurs in hospitalized patients but can also manifest in the community.
  • Sepsis is the most common clinical presentation, with rare instances of secondary septic localizations.

Purpose of the Study:

  • To summarize the epidemiology, clinical presentation, diagnosis, treatment, and prevention of candidemia in France.
  • To highlight key risk factors and diagnostic criteria for early detection.
  • To emphasize the importance of appropriate management strategies and preventive measures.

Main Methods:

  • Review of existing literature and clinical data on candidemia in France.
  • Analysis of diagnostic approaches and confirmed cases from blood cultures.
  • Evaluation of current treatment guidelines and preventive strategies.

Main Results:

  • Candidemia frequently leads to sepsis, with high overall mortality.
  • Risk factors include immunosuppression, vascular catheters, recent surgery, and specific antibiotic use.
  • Diagnosis is confirmed by positive blood cultures, with treatment involving echinocandins or fluconazole.

Conclusions:

  • Prompt diagnosis and treatment of candidemia are essential for reducing mortality.
  • Implementing preventive measures, such as judicious use of catheters and antibiotics, is critical.
  • Continued surveillance and research are needed to further combat invasive fungal infections.
Keywords:
candidiasis

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